Table 4.

Differentially regulated proteins involved in cytoskeleton organization and translation upon acute pan-neuronal dTau downregulation

	Identifier	Log 2 fold change	p Value
14-3-3ζ	FBgn0004907	−0.250421	0.023824*
Ank2	FBgn0261788	−0.16070	0.040059*
Eb1	FBgn0027066	−0.269836	0.038913*
dgt3	FBgn0034569	1.62118	0.031084*
Klp35D	FBgn0267002	−0.490059	0.016159*
Mtor	FBgn0013756	−0.376771	0.040521*
mud	FBgn0002873	2.61944	0.010824*
Pka-C1	FBgn0000273	−0.229651	0.009899*
Pka-R1	FBgn0259243	−0.217834	0.006967*
Rab11	FBgn0015790	−0.172639	0.018478*
Rbp	FBgn0262483	−0.173228	0.012758*
Strip	FBgn0035437	−0.457799	0.016759*
Arp2	FBgn0011742	−0.410359	0.009826*
bt	FBgn0005666	0.361831	0.034574*
btsz	FBgn0266756	−1.04969	0.049232*
didum	FBgn0261397	1.17976	0.001963*
mtm	FBgn0025742	−1.24456	0.034627*
SelR	FBgn0267376	−0.198595	0.039084*
vib	FBgn0267975	2.51317	0.001071*
WASp	FBgn0024273	−0.415598	0.003013*
zip	FBgn0265434	−0.16072	0.019419*
RpLP2	FBgn0003274	−0.22082	0.016296*
RpL9	FBgn0015756	0.363787	0.014304*
Ef1β	FBgn0028737	−0.18861	0.025385*
eIF-4B	FBgn0020660	1.22347	0.017551*
Elf	FBgn0020443	0.783829	0.029138*
EF2	FBgn0000559	−0.36835	0.001801*
eIF-2α	FBgn0261609	−0.16968	0.027685*
LeuRs	FBgn0053123	−1.95364	0.016296*
Fmr1	FBgn0028734	−0.8741	0.028043*
Dp1	FBgn0027835	−0.19861	0.03618*
U2af50	FBgn0005411	0.37609	0.024622*
qkr54B	FBgn0022987	0.619797	0.049061*
nito	FBgn0027548	−0.99659	0.045671*
La	FBgn0011638	0.505715	0.028674*
CG4612	FBgn0035016	−0.32493	0.011309*

Selected proteins, p values, and average log2 fold differences from four biological and two technical replicas have been calculated as described in Materials and Methods. Control animals are Elav-Gal4;TubG80^ts >+ vs Elav-Gal4;TubG80^ts > dtauRNAi induced for 3 d at 30°C. The log2 fold change becomes positive when RNAi > control and negative when control > RNAi. The t test was performed with a permutation-based FDR (0.05) calculation, and the p value determines the statistical significance (*p < 0.05). In bold are proteins whose levels were also found to be changed in the mutant (Tables 1, 2).