Table 5.

Differentially regulated proteins upon acute dTau loss that affect memory formation

Gene	Identifier	Log 2 fold change	p Value	References
Fmr1	FBgn0028734	−0.874096	0.028043*	1
lig	FBgn0020279	−1.006	0.032011*	2
14-3-3zeta	FBgn0004907	−0.250421	0.023824*	3
Ank2	FBgn0261788	−0.1607	0.040059*	4
CG4612	FBgn0035016	−0.324925	0.011309*	5
SLC22A	FBgn0037140	−0.850807	0.006731*	6
Fdh	FBgn0011768	0.29288	0.007593*	7
Pka-C1	FBgn0000273	−0.229651	0.009899*	8
Pka-R1	FBgn0259243	−0.217834	0.006967*	9
Sap47	FBgn0013334	−0.802852	0.003545*	10
Syn	FBgn0004575	−0.150291	0.005463*	11

Selected proteins, p value, and average log2 fold differences (four biological and three technical replicas) have been calculated as described in Materials and Methods. Control animals are Elav-Gal4;TubGal80ts >+ vs Elav-Gal4;TubGal80ts >dtauRNAi induced for 3 d at 30°C. The log2 fold change becomes positive when RNAi > control and negative when control > RNAi. The t test was performed with a permutation-based FDR (0.05) calculation, and the p value determines the statistical significance (*p < 0.05). In bold are proteins whose levels were also found to be changed in the mutant (Table 3). References: 1, Kanellopoulos et al. (2012); 2, Walkinshaw et al. (2015); 3, Philip et al. (2001); 4, Iqbal et al. (2013); 5, Khan et al. (2015); 6, Gai et al. (2016); 7, Hou et al. (2011); 8, Horiuchi et al. (2008); 9, Goodwin et al. (1997); 10, Saumweber et al. (2011); and 11, Godenschwege et al. (2004).