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. 2019 Oct 16;39(42):8408–8421. doi: 10.1523/JNEUROSCI.2851-18.2019

Figure 5.

Figure 5.

FKN/CX3CR1 signaling is required for gp120-induced synaptic degeneration. A, gp120-stimulated FKN expression in cortical cultures (N = 3 cultures/treatment). B, gp120-stimulated (by intrathecal administration) FKN expression in the mouse spinal cords (N = 6 mice/time point). C, Protein levels of PSD 95 and Syn I in the spinal cord of CX3CR1−/− or WT mice at day 7 after intrathecal injection with vehicle (Veh) or gp120 (N = 5 mice/group). D, Behavioral tests of gp120-induced mechanical allodynia in WT and CX3CR1−/− mice. Threshold of mechanical sensitivity in the hindpaw was measured by von Frey tests (N = 6 mice/group). Error bars indicate the mean ± SEM.