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. 2019 Oct 16;39(42):8291–8304. doi: 10.1523/JNEUROSCI.3154-18.2019

Figure 2.

Figure 2.

A role of RGS4 in symptoms of peripheral inflammation in female mice. a, Female RGS4KO mice show attenuated mechanical allodynia by day 8 after CFA injection to the ipsilateral hindpaw (two-way ANOVA followed by Bonferroni post hoc tests: F(1,27) = 14.08, *p = 0.03, ***p < 0.001, n = 14–15/group). b, Female RGS4KO mice show attenuated responses to cold (0°C) at 9 d after CFA treatment compared with the RGS4WT group (unpaired t test: t(27) = 3.219, **p = 0.003, n = 14–15/group). c, Prevention of RGS4 action improves voluntary wheel running. Female RGS4KO mice show higher running wheel activity compared with RGS4WT controls at 13 d after left hindpaw CFA injection, suggesting recovery from chronic pain states. Baseline responses are indistinguishable between phenotypes. Bars represent the percentage of naive baseline responses (two-way ANOVA followed by Bonferroni post-tests: F(1,26) = 5.106, *p = 0.04, n = 7–8/group). d, In contrast, both RGS4WT and RGS4KO female mice show identical responses in the Hargreaves assay for thermal hyperalgesia (two-way ANOVA: F(1,27) = 0.2289, n = 14–15/group). e, Female RGS4WT and RGS4KO mice show similar licking/flinching levels during the first 40 min of the formalin test, but after this time point RGS4KO mice show recovery from nocifensive states (two-way ANOVA followed by Bonferroni post hoc tests: F(1,14) = 3.256, **p = 0.008, n = 7–9/group).