Figure 5.

THL-specific RNA-Seq profiling of RGS4KO in groups of naive and CFA-treated mice. a, Experimental time line showing that THL tissue from male groups of mice was collected 18 d after the induction of peripheral inflammation (a time point that RGS4KO mice show recovery from mechanical allodynia). b–d, Venn diagram depicting the number of genes affected in each group and their direction of regulation suggest that long-term peripheral inflammation promotes distinct gene expression adaptations between genotypes (b) and associated gene ontology (GO) categories (c, d). Bar graphs show GO of genes uniquely regulated by pain (CFA) in the THL of RGS4WT (black color) and RGS4KO (gray color) mice. Only GO terms with p < 0.05 are depicted.