Table 2.

Hazard ratios and C statistics for incident CAD of different baseline blood pressure measures, adjusted for gender, age, age of diabetes onset, HbA1c, and antihypertensive medication use

BP measure	Cox model		C-statistics
	HR (95% CI) per SD	P value	C-statistic (95% CI)
Overall	n = 605, events = 219
SBP	1.35 (1.17, 1.56)	<0.001	0.789 (0.752, 0.827)*
DBP	1.30 (1.12, 1.51)	<0.001	0.784 (0.746, 0.822)*
PP	1.20 (1.03, 1.39)	0.021	0.770 (0.729, 0.810)
MAP	1.35 (1.17, 1.56)	<0.001	0.789 (0.747, 0.831)*
Stratified by age
	Baseline age < 35 years
	n = 500, events = 150
SBP	1.31 (1.10, 1.57)	0.003	0.760 (0.705, 0.815)
DBP	1.33 (1.12, 1.59)	0.001	0.773 (0.719, 0.827)*
PP	1.07 (0.88, 1.29)	0.500	0.748 (0.691, 0.805)
MAP	1.35 (1.14, 1.61)	<0.001	0.770 (0.713, 0.826)*
	Baseline age ≥ 35 years
	n = 105, events = 69
SBP	1.38 (1.06, 1.79)	0.018	0.656 (0.567, 0.764)
DBP	1.08 (0.78, 1.49)	0.640	0.640 (0.551, 0.729)
PP	1.49 (1.15, 1.94)	0.003	0.658 (0.562, 0.753)
MAP	1.24 (0.92, 1.68)	0.156	0.648 (0.545, 0.751)
Stratified by HbA1c
	Baseline HbA1c < 9%
	n = 380, events = 141
SBP	1.35 (1.12, 1.62)	0.001	0.751 (0.696, 0.806)
DBP	1.37 (1.13, 1.66)	0.001	0.768 (0.715, 0.822)*
PP	1.13 (0.94, 1.37)	0.202	0.731 (0.678, 0.784)
MAP	1.39 (1.16, 1.68)	<0.001	0.774 (0.710, 0.838)*
	Baseline HbA1c ≥ 9%
	n = 225, events = 78
SBP	1.29 (1.02, 1.63)	0.018	0.840 (0.780, 0.900)
DBP	1.20 (0.95, 1.52)	0.135	0.836 (0.773, 0.898)
PP	1.32 (1.01, 1.72)	0.043	0.838 (0.786, 0.890)
MAP	1.26 (1.00, 1.60)	0.050	0.839 (0.792, 0.887)

*P < 0.05 compared with PP. P > 0.05 for the rest of pairwise comparisons between different blood pressure measures (SBP, DBP, PP, and MAP). Abbreviations: BP, blood pressure; CAD, coronary artery disease; CI, confidence interval; DBP, diastolic blood pressure; HbA1c, hemoglobin A1c; HR, hazard ratio; MAP, mean artery pressure; PP, pulse pressure; SBP, systolic blood pressure.