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. 2019 Oct 9;7:241. doi: 10.3389/fbioe.2019.00241

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Copyright © 2019 Choi, Seo, Park, Lee, Song, Kim, Park, Kim, Lee, Chun and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic overview of metabolic pathway for DHS biosynthesis in E. coli. Red crosses denote disrupted genes and bold blue arrows denote steps that are overexpressed. Dashed arrows represent two or more steps. G6P, glucose-6-phosphate; PEP, phosphoenolpyruvate; PYR, pyruvate; AcCoA, acetyl-coenzyme A; OAA, oxaloacetate; CIT, citrate; E4P, erythrose4-phosphate; DAHP, 3-deoxy-D-arabinoheptulosonate-7-phosphate; DHQ, 3-de-hydroquinate; DHS, 3-dehydroshikimate; SA, shikimic acid; PCA, protocatechuate; CA, catechol, MA, muconic acid. ptsG, glucose specific sugar: phosphoenolpyruvate phosphotransferase; galP, D-galactose transporter; zwf, glucose-6-phosphate 1-dehydrogenase; tktA, transketolase; tyrR, tyrosine dependent transcriptional regulator; pykF, pyruvate kinase 1; pykA, pyruvate kinase 2; ppsA, phosphoenolpyruvate synthase; pckA, phosphoenolpyruvate carboxykinase; aroG, DAHP synthase; aroF, DAHP synthase; aroB, DHQ synthase; aroD, DHQ dehydratase; aroE, shikimate dehydrogenase: asbF^Eopt, 3-dehydroshikimate(DHS) dehydratase; pcaG/H, codon-optimized PCA deoxygenase; aroY^Eopt, codon-optimized PCA decarboxylase; catA^Eopt, codon-optimized CA 1,2 -dioxygenase.