Fig. 5.

High FA2H expression is associated with increased 2-hydroxyHexCers in lung cancer. Linear regression of the level of 2-hydroxyHexCer (2-OH HexCer) versus FA2H (A) and UGT8 (B) mRNA relative expression in adenocarcinoma (AD) high (red), AD low (blue), squamous (black), or neuroendocrine (Neuro) (green) lung cancer tissues. C: mRNA expression rank for FA2H and UGT8 among lung cancer samples are plotted on the x and y axes. Circle diameter indicates the 2-OH HexCer levels. Average 2-OH HexCer ± SEM for each quadrant is indicated. Black lines are the regression curves for all samples; red line is for AD high only (n = 20–22).