TABLE 1.
Overview of the binding partners, involved in the binding of EBs to the surface of host cell for specific chlamydial species.
Chlamydial adhesin | Host receptor | Species | References |
LPS | Cystic fibrosis transmembrane conductance regulator (CFTR) | C. trachomatis | Ajonuma et al., 2010 |
MOMP (CT681) | mannose 6-phosphate receptor/insulin-like growth factor receptor 2 (M6PR/IGFR2) via N-Man-Glyc | C. pneumoniae | Puolakkainen et al., 2005 |
CT017 (Ctad1) | Beta-1 integrin (ITGB1) | C. trachomatis | Stallmann and Hegemann, 2016 |
Pmp21 | Epidermal growth factor receptor (EGFR/ERBB) | C. pneumoniae | Mölleken et al., 2013 |
Hsp70 | 3′sulfogalactolipid (3′SGL) | C. trachomatis | Mamelak et al., 2001 |
? | Fibroblast growth factor receptor (FGFR) via Fibroblast growth factor 2 (FGF2) | C. trachomatis | Kim et al., 2011 |
? | Platelet-derived growth factor receptor (PDGFR) | C. trachomatis | Elwell et al., 2008 |
? | Ephrin receptor A2 (EPHA2) | C. trachomatis | Subbarayal et al., 2015 |
? | Apolipoprotein E4 | C. pneumoniae | Gerard et al., 2008 |
All Pmps | ? | C. trachomatis | Becker and Hegemann, 2014 |
Pmp6 | ? | C. pneumoniae | Mölleken et al., 2010 |
Pmp20 | ? | C. pneumoniae | Mölleken et al., 2010 |