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. 2019 Jul 19;160(11):2600–2617. doi: 10.1210/en.2019-00410

Figure 5.

Figure 5.

Cell cycle analysis via flow cytometric analysis. Significant induction of a G1-phase cell cycle arrest in MPC cells by BYL719, everolimus, or sunitinib alone and (even stronger) by the BYL719/everolimus and sunitinib/everolimus combination treatments at 24 h of treatment. Significant induction of a G1-phase cell cycle arrest in MTT cells by everolimus (10 nM) and sunitinib (1 µM/2 µM) and (even stronger) by the BYL719/everolimus and sunitinib/everolimus combination treatment at 24 h of treatment. The arithmetic means and SD of at least three independent experiments are shown. *Statistically significant differences in comparison with the DMSO control (P < 0.05).