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. 2019 Jul 19;160(11):2600–2617. doi: 10.1210/en.2019-00410

Figure 9.

Figure 9.

Significant MPC/MTT spheroid shrinkage or complete spheroid collapse after fractionated treatment with 5 µM BYL719, even stronger shrinkage, as compared with BYL719 alone, or an early complete collapse of the spheroids in several experiments after fractionated treatment with the BYL719/everolimus combination and spheroid growth inhibition after fractionated treatment with 25 nM everolimus. Spheroids were treated with different concentrations of BYL719 and everolimus after completed spheroid formation (day 4) and on days 7, 11, and 14 (fractionated treatment). Growth was monitored over 18 d. The arithmetic means and all single values of each experiment of at least three independent experiments are shown. *Statistically significant different results in comparison with the DMSO control (P < 0.05).