Figure 2.

Neural creatine concentration after supplementation. a, Mean Cr concentration detected in the sensorimotor cortex increased after 1 week of dietary CrM supplementation (black bars) compared to PLA (white bars). Data were recorded using ¹H MRS, transformed to an absolute quantity (in millimoles per liter) and corrected for the proportion of gray and white matter present in the volume of interest. Bars show the mean ± SEM. *p < 0.05. b, Amplitude of the Cr + PCr peaks from ¹H MRS. An example spectra acquired at 3 T from the sensorimotor cortex of one participant is shown. Resonances at 3.069 and 3.960 ppm represent the primary and secondary Cr + PCr peaks, respectively.