Table 3.
Effect of point mutation predictions with other amino acids.
| Variant | PROVEAN score | PROVEAN prediction (cut-off = −2.5) | Duet ΔΔG | DUET prediction |
|---|---|---|---|---|
| S830A | −2.853 | Deleterious | −0.636 | Mildly deleterious |
| S830V | −5.704 | Deleterious | −0.074 | Mildly deleterious |
| S830L | −5.701 | Deleterious | 0.35 | Stabilizing |
| S830G | −3.808 | Deleterious | −1.025 | Mildly deleterious |
| S830W | −6.659 | Deleterious | −0.924 | Mildly deleterious |
| S830T | −2.853 | Deleterious | −0.445 | Mildly deleterious |
| S830Q | −3.805 | Deleterious | −0.428 | Mildly deleterious |
| S830E | −3.807 | Deleterious | −0.339 | Mildly deleterious |
| S830C | −4.755 | Deleterious | −0.245 | Mildly deleterious |
| S830R | −4.756 | Deleterious | −0.336 | Mildly deleterious |
| S830P | −4.758 | Deleterious | −0.764 | Mildly deleterious |
| S830D | −3.808 | Deleterious | −0.54 | Mildly deleterious |
| S830F | −5.705 | Deleterious | −0.689 | Mildly deleterious |
| S830I | −5.703 | Deleterious | 0.327 | Stabilizing |
| S830H | −4.758 | Deleterious | −1.604 | Mildly deleterious |
| S830N | −2.855 | Deleterious | −0.619 | Mildly deleterious |
| S830M | −4.752 | Deleterious | 0.248 | Stabilizing |
| S830Y | −5.706 | Deleterious | −0.446 | Mildly deleterious |
| S830K | −3.805 | Deleterious | −0.211 | Mildly deleterious |