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. 2019 Oct 3;4(19):e129110. doi: 10.1172/jci.insight.129110

Figure 7. Protected phenotype of Kiaa0317–/– mice requires SOCS2.

Figure 7

Mice were infected i.t. with lentivirus encoding control shRNA or Socs2 shRNA (1 × 107 PFU/mouse) prior to LPS exposure (3 mg/kg). Following exposure, mice were euthanized, and lungs were lavaged with saline and harvested. (A and B) Protein concentration and cell count measurements from BALF. (C–E) BALF cytokine concentrations. (F–H) BALF leukocyte differential. In A–H, data represent mean values ± SEM (n = 5–6 mice). (I) Histology of murine lungs following H&E staining; scale bar: 200 μm. *P < 0.05, **P < 0.01, ***P < 0.001,****P < 0.0001 compared with control shRNA-Kiaa0317+/+ mice or as indicated; 1-way ANOVA with Tukey’s multiple-comparisons test.