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. 2019 Oct 3;4(19):e129183. doi: 10.1172/jci.insight.129183

Figure 1. SMC CYB5R3–KO mice have a significantly elevated MAP and reduced heart rate compared with WT mice under physiological conditions.

Figure 1

(A) The experimental design where WT (n = 10, gray) and SMC CYB5R3–KO (n = 10, red) mice after tamoxifen treatment were implanted with telemetry units and BP monitored continuously for 24 hours. (B) SMC CYB5R3–KO mice have a significantly increased MAP compared with WT mice. (C) SMC CYB5R3–KO mice have a significantly decreased heart rate compared with WT mice. (B and C) P values represent significant differences between WT and SMC CYB5R3–KO by 2-way repeated- measures ANOVA with *P < 0.05 by Sidak multiple comparison tests. Error bars represent ± SEM.