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. 2019 Oct 16;14(10):e0223384. doi: 10.1371/journal.pone.0223384

Table 2. Presence of collateral symptoms in both current and former users, as well as their disappearance after the end of the cycle.

Variables Total n (%) Former Users
n (%)
Current Users
n (%)
P
Collateral Symptoms
    Yes 643 (89,4%) 466a (88,8%) 177a (91,2%) 0,338
    No 76 (10,6%) 59a (11,2%) 17a (8,8%)
Symptoms
    Increased Libido 327 (45,5%) 213a (40,6%) 114b (58,8%) 0,0001
    Acne 308 (42,8%) 213a (40,6%) 95b (49,0%) 0,043
    Irritability / Aggressiveness 233 (32,4%) 157a (29,9%) 76b (39,2%) 0,018
    Headache 159 (22,1%) 119a (22,7%) 40a (20,6%) 0,557
    Decreased Libido 111 (15,4%) 77a (14,7%) 34a (17,5%) 0,346
    Gynecomastia 97 (13,5%) 63a (12,0%) 34a (17,5%) 0,054
    Hypertension 91 (12,7%) 55a (10,5%) 36b (18,6%) 0,004
    Change in Menstrual Cycle 73 (10,2%) 58a (11,0%) 15a (7,7%) 0,191
    Deepening of the Voice 71 (9,9%) 50a (9,5%) 21a (10,8%) 0,604
    Depression 50 (7,0%) 26a (5,0%) 24b (12,4%) 0,001
    Dependency 31 (4,3%) 16a (3,0%) 15b (7,7%) 0,006
    Vomiting / Nausea 25 (3,5%) 17a (3,2%) 8a (4,1%) 0,545
    Other 59 (8,2%) 48a (9,1%) 11a (5,7%) 0,132
Symptoms Disappeared After Cycle
    Yes 555 (77,2%) 415a (79,0%) 140a (72,2%) 0,025
    No 98 (13,6%) 71a (13,5%) 27a (13,9%)
    Some 66 (9,2%) 39a (7,4%) 27b (13,9%)

Proportion z test. The different letters in the lines indicate significant differences (p <0.05).