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. 2019 Oct 4;15(10):e1008411. doi: 10.1371/journal.pgen.1008411

Fig 6. Immunohistochemistry of the white matter in the centrum semiovale of the cerebrum.

Fig 6

(A) Affected puppy no. 1 and (B) age matched healthy control no. 1009. (A) In affected puppies, only single NogoA+ oligodendrocytes are detectable (arrows). Vacuolization and loosening of the parenchyma indicate the moderate edema. Inset shows a NogoA+ oligodendrocyte at a higher magnification. (NogoA). (B) Age matched control animals show numerous NogoA+ myelinating oligodendrocytes. Inset shows NogoA+ oligodendrocytes at a higher magnification. (NogoA). (C) Statistical analysis of NogoA-immunohistochemstry shows significantly decreased numbers of myelinating oligodendrocytes in the centrum semiovale of the affected Schnauzer puppies (n = 4, no.1, 2, 3 and 4) in comparison to age matched control animals (n = 4, no. 1009, 1010, 1011 and 1012). Box and whisker plots display median and quartiles with maximum and minimum values. Significant difference (p ≤ 0.05, Mann-Whitney U-test) is labeled by asterisk.