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. 2019 Oct 4;15(10):e1008411. doi: 10.1371/journal.pgen.1008411

Fig 8. Pedigree of Standard Schnauzers used for linkage analysis and autozygosity mapping.

Fig 8

Filled symbols represent dogs with leukodystrophy. For a better overview, the pedigree was drawn only with a subset of the closely related dogs. Two litters with a total of four affected dogs and their parents were used for linkage analysis. The four cases no. 1–4 were used for autozygosity mapping. Numbers indicate dogs, from which DNA samples were available. The solitary symbols in the square represent 8 additional affected Standard Schnauzers, for which no pedigree data was available (no. 5–12). For these dogs, only FFPE material was available for DNA isolation. The resulting DNA was of insufficient quality for genotyping on microarrays, but could be used to determine the genotypes at the TSEN54:c.371G>A variant. The TSEN54:c.371G>A genotypes for all dogs with DNA samples are indicated in the figure.