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. 2019 Oct 4;15(10):e1008411. doi: 10.1371/journal.pgen.1008411

Fig 9. Details of the TSEN54:c.371G>A variant.

Fig 9

(A) Sanger electropherograms from dogs with the three different genotypes confirm the presence of the variant. (B) A multiple species alignment of the TSEN54 amino acid sequence illustrates that the variant affects a highly conserved region of the protein. The wildtype glycine is perfectly conserved across diverse vertebrates. The yeast (S. cerevisiae) SEN54 protein shows overall low amino acid sequence homology with the vertebrate TSEN54 ortholog. However, the glycine residue is conserved and sits within a structurally conserved region consisting of an alpha-helix followed by a beta-sheet.