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. 2019 Oct 16;5(10):eaax5108. doi: 10.1126/sciadv.aax5108

Fig. 5. AβC7-1 and AβC7-14 inhibit Aβ42 aggregation in vivo.

Fig. 5

(A) Normalized motility (left) and normalized speed of movement (right) of Aβ42 and wild-type worms in the absence and presence of 40 μΜ AβC7-1 and 5 μΜ AβC7-14 during days 5 to 10 of adulthood. (B) Motility (left) and speed (right) of individual Aβ and wild-type worms in the absence and presence of AβC7-1 and AβC7-14 at day 7 of adulthood. (C) Total fitness (51) of the worms as in (B). (D) Relative fluorescence of Aβ42 and wild-type worms at day 7 of adulthood showing a 50 to 60% decrease in Aβ42 aggregate formation in the presence of AβC7-1 and AβC7-14. (E) Representative images from (D). In (A) to (C), ~200 worms were analyzed on average, while in (D), 25 worms were analyzed in total. In all panels, mean values ± SEM are presented (n = number of worms tested in one experiment). Statistical significance is denoted by *P ≤ 0.05 and ****P ≤ 0.0001, for differences to the “No peptide Aβ worms” sample.