(A) A ribbon diagram of the mTORC1-RHEB-RagA/C-Ragulator complex.
RAPTOR-RagA/C was superimposed on RAPTOR in mTORC1-RHEB complex (PDB ID 6BCU
(3)). The CRD of the
mTORC1-RagA/C-RHEB complex was superimposed onto the CRD of the crystal
structure of Ragulator-CRD domain complex (PDB ID 6EHR (35)).
(B) Expanded view of the Ragulator/Rags/RAPTOR interface.
(C) A model of the complex on a lysosomal membrane. The
lipid-modified regions of LAMTOR1 and RHEB that anchor them to membranes are
depicted in arbitrary conformations.