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. Author manuscript; available in PMC: 2020 Apr 11.
Published in final edited form as: Science. 2019 Oct 11;366(6462):203–210. doi: 10.1126/science.aax3939

Fig. 6. Model of mTORC1-RHEB-RagA/C-Ragulator complex.

Fig. 6

(A) A ribbon diagram of the mTORC1-RHEB-RagA/C-Ragulator complex. RAPTOR-RagA/C was superimposed on RAPTOR in mTORC1-RHEB complex (PDB ID 6BCU (3)). The CRD of the mTORC1-RagA/C-RHEB complex was superimposed onto the CRD of the crystal structure of Ragulator-CRD domain complex (PDB ID 6EHR (35)).

(B) Expanded view of the Ragulator/Rags/RAPTOR interface.

(C) A model of the complex on a lysosomal membrane. The lipid-modified regions of LAMTOR1 and RHEB that anchor them to membranes are depicted in arbitrary conformations.