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. Author manuscript; available in PMC: 2019 Oct 16.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):e159–e170. doi: 10.1161/ATVBAHA.118.310227

Figure 1. MiRNAs regulate endothelial senscense and inflammation in response to cytokines, metabolic stimuli and disturbed flow.

Figure 1

MiRNAs, such as miR-34a, miR-217, and miR-146, mediate proatherotic factors induced suppression of the key anti-senesence factor Sirtuin 1 (SIRT1) transcript in ECs. Reactive oxygen species (ROS) sensitive miRNA such as miR-200c mediated inhibition of SIRT1, MnSOD and CAT and enhancement in endothelial sensense by downregulating zinc finger E-box binding homeobox 1(ZEB1) or Forkhead box protein O1(FOXO1) transcription. Shear stress enhanced miR-19a impairs the cellular self-repair by inhibiton of cyclin D. Endothelial miR-19a is also transferred in microparticles and mediates proinflammation response in neighboring adipocytes in a paracrine manner. Moreover, disturbed flow and hyperlipidemia decrease miR-21 and mir126 expression in ECs, resulting in derepression of NF-kB medicate VCAM-1 production, which triggers inflammation.