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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Cancer Discov. 2019 Jul 25;9(10):1406–1421. doi: 10.1158/2159-8290.CD-19-0138

Figure 7. Speculative model of the LCH developmental hierarchy and underlying regulatory mechanisms.

Figure 7

Schematic representation of the developmental hierarchy in LCH lesions based on the combined analysis of single-cell transcriptomes (Fig. 2 and 3) and epigenome data from prospectively sorted LCH cell subsets (Fig. 5 and 6).