Extended Data Figure 6. hkCP and dCP enhancers in S2 cells are associated with genes of different functions and core promoter elements.

a, Gene ontology (GO) analysis of genes next to hkCP and dCP-specific enhancers in S2 cells using different enhancer-to-gene assignment strategies (top-left: ‘closest TSS’ as in Figure 2, top-right: ‘1kb TSS’, bottom-left: ‘gene loci’; see Methods for details). Shown are 20 non-redundant GO categories selected from the 100 most significantly enriched categories associated with each enhancer class (see Supplementary Tables 11-13 for all categories). b, Enrichment of core promoter elements at genes next to hkCP and dCP-specific enhancers in S2 cells. Similar analysis as in Figure 2e, however using different enhancer-to-gene assignment strategies (see Methods for details). Consistent with Figure 2e, core promoters of genes assigned to hkCP-specific enhancers are enriched in Motifs 1, 5, 6, 7 and DRE, while core promoters of genes assigned to dCP-specific enhancers are enriched for TATA box, Initiator, MTE and DPE motifs, irrespective of the assignment strategy.