Extended Data Figure 7. Housekeeping and developmental core promoters differ characteristically in their global enhancer preferences.

As Figure 3b yet including biological replicates with an independently cloned BAC library covering around 5MB of genomic sequence (BAC) and assessing the Pearson correlation coefficient at each position along these regions (GW: genome-wide screens as in Figure 3b). The similarity observed for the TATA box and DPE containing core promoters (hsp70, pnr, and DSCP [dCP]) suggest that differences related to these core promoter elements might be more subtle or related to alternative mechanisms, including the potential preferences of more proximal or distal enhancers⁴² or Polymerase RNA polymerase II pausing and the dynamics versus stochasticity of initiation and elongation^43,44,45.