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. Author manuscript; available in PMC: 2019 Oct 16.
Published in final edited form as: Nature. 2014 Dec 15;518(7540):556–559. doi: 10.1038/nature13994

Extended Data Figure 4. hkCP and dCP STARR-seq signal in S2 cells around different core promoter types.

Extended Data Figure 4

Average hkCP (top) and dCP (bottom) S2 STARR-seq enrichment in 40kb intervals around transcription starting sites (TSS) that contain different combinations of known core promoter motifs. Shown are (left to right) TATA-Initiator (179 TSSs), Initiator (that do not contain either TATA or DPE; 1901), Initiator-DPE (100), TCT (303) and Motif1-Motif6 (266). According to their motif contents, the first 3 are developmental-type core promoters and the last 2 are housekeeping-type core promoters. Indeed, only the housekeeping-type core promoters show a strong enrichment of hkCP S2 STARR-seq signals at the TSS, which is not seen for the dCP STARR-seq signal (due to enhancer–core promoter specificity) nor for the developmental-type core promoters (due to the dCP enhancers location at more distal sites).