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R853Q-induced gating pore is permeable to guanidinium. Single-cell representative data (n = 1 WT, 1 R853Q). Leak currents in oocytes expressing either WT (black squares) or R853Q (red circles) hNav1.2 in the absence (empty symbols) and presence (filled symbols) of guanidinium (Gu), a cation believed to be permeant to the gating pore created by the R853Q mutation in hNav1.2. Figure Contributions: Fenfen Wu performed data collection and analysis.
