Table 1. Pathologic complete response rates after neoadjuvant SABR for resectable early-stage NSCLC.
Author | Trial name | Year | Treatment regimen | N surgically-resected* | pCR rate | Time between neoadjuvant therapy and resection | Comment |
---|---|---|---|---|---|---|---|
Palma et al. | MISSILE-NSCLC (NCT02136355) | 2019 | Neoadjuvant SABR plus surgery | 35 | 60% | 10 weeks | 2-year OS: 77% |
2-year local control: 100% | |||||||
2-year regional control: 53% | |||||||
2-year distant control: 76% |
*, one pathology specimen was improperly fixated in formalin and thus could not be analyzed. SABR, stereotactic ablative radiotherapy; N, number of patients; NSCLC, non-small cell lung cancer; pCR, pathologic complete response.