Table 3.
Bisphosphonate use and cause-specific mortality in the matched cohort
| Number (%) of deaths | ||||
|---|---|---|---|---|
| Cause | BP | Control | HR (95% CI) | P |
| All causes | 1313 (100) | 1609 (100) | 0.85 (0.79–0.91) | < 0.001 |
| Cardiovascular | 422 (32.1) | 505 (31.4) | 0.87 (0.76–0.99) | 0.03 |
| Arrhythmia | 55 | 79 | 0.72 (0.51–1.01) | 0.06 |
| Cerebrovascular | 123 (9.4) | 157 (9.8) | 0.82 (0.64–1.03) | 0.09 |
| Respiratory | 123 (9.4) | 152 (9.4) | 0.84 (0.66–1.06) | 0.14 |
| Pneumonia | 36 | 46 | 0.81 (0.52–1.25) | 0.34 |
| Dementia/Alzheimer’s disease/senility | 169 (12.9) | 239 (14.9) | 0.74 (0.61–0.90) | 0.003 |
| Neoplasm | 219 (16.7) | 233 (14.5) | 0.97 (0.80–1.16) | 0.73 |
| Injury from accident | 40 (3.0) | 54 (3.4) | 0.76 (0.51–1.15) | 0.20 |
| Other | 208 (15.8) | 254 (15.8) | 0.85 (0.71–1.02) | 0.08 |
| Unspecified | 9 (0.7) | 15 (0.9) | 0.62 (0.27–1.43) | 0.26 |
BP bisphosphonate, HR hazard ratio, CI confidence interval