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. 2019 Oct 6;7(19):2930–2941. doi: 10.12998/wjcc.v7.i19.2930

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Correlation between relative expression of miR-489 and miR-21 in serum and TNM stage of melanoma in the research group. A: The relative expression of serum miR-489 decreased with the increase of TNM stage (P < 0.05). ^aP < 0.05; ^cP < 0.001. B: The relative expression of serum miR-21 increased with the increase of TNM stage (P < 0.05). ^aP < 0.05; ^cP < 0.001. C: The relative expression of serum miR-489 was negatively correlated with TNM stage (r = -0.612, P < 0.001). D: The relative expression of serum miR-21 was positively correlated with TNM stage (r = 0.609, P < 0.001).