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CP-AMPA receptors at the spinal cord level contribute to diabetic neuropathic pain. (A and B) Time course of the inhibitory effect of of IEM-1460 injected intrathecally on the withdrawal threshold in response to a noxious pressure stimulus (A) and von Frey filaments (B) in seven diabetic rats and six control rats. Data are shown as means ± S.E.M. *P < 0.05; **P < 0.01; ***P < 0.001 compared with respective baseline values (time 0; repeated measures ANOVA with Dunnett’s post-hoc test).
