Fig. 2.

Final day body weight, food consumption, and running wheel measures in drug-naive rats. The final day in the experimental paradigm for adolescents was day 4, whereas the final day for adults was day 5. Because animals used for chronoamperometry and cocaine-induced locomotion were removed prior to completion of their full fourth (adolescents) or fifth (adults) day, only data from drug-naive rats are shown here. (A) Adolescent day 4 body weight; (B) adult day 5 body weight; (C) adolescent and (D) adult food consumption over the past 23 hours as a percentage of the individual animal’s body weight; (E) adolescent and (F) adult running wheel activity over the last 23 hours for EC and ABA animals. No running wheel activity is shown for CC and FC animals because their wheels were locked and therefore they could not run in the wheel. Data were analyzed within each age group with a two-way (sex × condition) ANOVA with Tukey-Kramer’s post-hoc tests where appropriate. Data are graphed as mean + S.E.M. *P < 0.05; **P < 0.01; ***P < 0.001 vs. same-sex condition, indicated by color of asterisk(s), within the same age group. ^##P < 0.01 vs. same condition in females of same age group. Number of animals is indicated at base of each bar.