Table 2.
Retinal nerve fiber thicknesses and visual functions for multiple sclerosis and neuromyelitis optica spectrum disorder.
| Neuromyelitis optica spectrum disorder | Multiple sclerosis | p-value | |||||
|---|---|---|---|---|---|---|---|
| Unaffected | Affected | Unaffected | Affected | ||||
| Single ON | Multiple ON | Single ON | Multiple ON | Single ON | |||
| (N = 45) | (N = 60) | (N = 41) | (N = 38) | (N = 33) | (N = 5) | NMOSD vs. MS | |
| RNFL thickness, μm, mean (SD) | |||||||
| Average | 105.5 (11.9) | 76.0 (24.8) | 49.9 (16.4) | 102.7 (11.9) | 95.2 (14.0) | 77.4 (11.4) | <0.001 |
| Temporal | 79.0 (15.7) | 57.0 (21.8) | 40.6 (14.2) | 73.9 (17.3) | 71.4 (24.8) | 44.2 (12.2) | 0.008 |
| Inferior | 137.9 (19.3) | 98.9 (36.3) | 58.4 (27.1) | 133.3 (16.3) | 123.2 (20.8) | 99.4 (13.2) | <0.001 |
| Nasal | 78.6 (16.3) | 56.3 (18.1) | 43.7 (11.2) | 78.6 (14.6) | 68.8 (12.4) | 65.2 (8.9) | <0.001 |
| Superior | 126.7 (18.6) | 91.9 (34.9) | 57.0 (21.9) | 124.5 (17.4) | 117.2 (18.8) | 100.4 (20.0) | <0.001 |
| Macular volume, mm3, mean (SD) | |||||||
| 6.77 (0.43) | 6.07 (0.77) | 5.50 (0.43) | 6.75 (0.36) | 6.58 (0.37) | 6.27 (0.41) | <0.001 | |
| Visual acuity, LogMAR, median (mean) | |||||||
| 100% contrast | 0.10 (0.26) | 0.75 (0.93) | 1.60 (1.63) | 0.20 (0.35) | 0.10 (0.33) | 1.30 (1.10) | <0.001 |
| 2.5% contrast | 0.60 (0.81) | 1.80 (1.24) | 1.80 (1.74) | 0.50 (0.60) | 0.80 (1.02) | 0.80 (1.00) | 0.118 |
MS, multiple sclerosis; NMOSD, neuromyelitis optica spectrum disorder; ON, optic neuritis; EDSS, Expanded Disability Status Scale; RNFLT, retinal nerve fiber layer thickness; p-values after adjusting age and disease duration.