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. 2019 Oct 16;9:14843. doi: 10.1038/s41598-019-50903-9

Figure 6.

Figure 6

DP cells are more frequently cycling in tissue from BRCA1 mutation carriers. (A) Normal tissue from a woman with known BRCA1 mutation immunostained for K14 (green), cell cycle marker Ki67 (blue) and luminal keratin marker CAM5.2 (red). Arrowhead marks a Ki67+ DP cell. Bar, 25 µm. Lower panel image subsets are shown in single color channels, including DAPI nuclear stain (white). Bar: 10 µm. (B) Dot plot comparing the proportion of Ki67+ cells in the DP population between women with BRCA1 mutations and women with no known mutations. *p < 0.017 (normal: n = 7; BRCA1 mutated: n = 7) by Mann Whitney test.