Table 2.
Summary of the results of the hierarchical regression models testing for the effects of genetic and lifestyle risk variables on fornix and hippocampus mediator variables. pBHadj, 5% False Discovery Rate Benjamini-Hochberg adjusted p-values (significant p-values are highlighted in bold). BP = blood pressure, FH = family history, ICV = intracranial volume, ISOSF = isotropic signal fraction, MPF = macromolecular proton fraction, WHR = waist-hip-ratio.
| Outcome variables | Adjusted R2 | Predictors in final regression model |
|---|---|---|
| Fornix MPF | 0.24 (p < 0.001) |
Age (p BHadj < 0.001) WHR (p BHadj = 0.045) |
| Fornix R1 | 0.28 (p < 0.001) |
Age (p BHadj < 0.001) ICV (p BHadj = 0.026) Alcohol (p BHadj = 0.03) WHR (p BHadj = 0.04) |
| Fornix kf | 0.23 (p < 0.001) |
Age (p BHadj < 0.001) WHR (pBHadj = 0.07) |
| Fornix ISOSF | 0.32 (p < 0.001) |
Age (p BHadj < 0.001) ICV (pBHadj = 0.05) Sex (p BHadj = 0.004) |
| Right hippocampal ISOSF | 0.36 (p < 0.001) |
Age (p BHadj < 0.001) ICV (p BHadj = 0.026) Sex (p BHadj = 0.007) Diastolic BP (pBHadj = 0.07) FH (pBHadj = 0.07) |