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. 2019 Oct 16;9:14852. doi: 10.1038/s41598-019-51281-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased oxidative stress and decreased BDNF/TrkB expression in glaucomatous marmosets. (a) 4-HNE expression in the retina detected by immunohistochemistry. Scale bar: 100 µm. (b) Quantitative analyses of the intensity of 4-HNE. n = 3 per group. (c) 4-HNE expression in the blood detected by immunoblot analyses. n = 9 (aged) and 3 (glaucoma). (d) GSH concentrations in the blood. n = 4 (aged) and 3 (glaucoma). (e) BDNF and TrkB in the optic nerve head (ONH) and retina detected by immunohistochemistry. Scale bar: 100 µm. (f,g) Quantitative analyses of the intensity of BDNF (f) and TrkB (g). n = 3 per group. (h) BDNF concentrations in the CSF. n = 3 per group. The data are presented as means ± S.E.M. *P < 0.05; **P < 0.01, ***P < 0.001.