Figure 4.

PGV-1 suppresses tumor formation in vivo. (a) Experimental design of testing for anti-tumor activity of curcumin and PGV-1. (b-d) K562 cells (2.5 × 10⁶ cells) were transplanted s.c. into the flanks of mice. Mice were then treated every 2 days with curcumin (20 mg/kg BW) in corn oil via i.p., curcumin in PBS via p.o., and control (PBS, p.o.). Tumor sizes were measured every 2 days during this period (b). After 18 days, mice were sacrificed, tumors were taken (c), and tumor weights were measured (d). (e-i) K562 cells (2.5 × 10⁶ cells) were transplanted s.c. into the flanks of mice. Mice were then treated every 2 days with curcumin and PGV-1 in PBS via p.o., and control (PBS, p.o.). The tumor sizes were measured every 2 days (e). After 18 days, mice were sacrificed and tumors were taken (f) and measured (g). The body weights were measured every 2 days (h, left panel), and, after 18 days, they were compared (h, right panel). The white and red cells in peripheral blood were counted at the time of sacrifice (i). Data are shown as means ± SD. In panels D, G, H, and I, medians are also shown. ns; not significant.