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. 2019 Oct 16;9:14837. doi: 10.1038/s41598-019-50781-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The stability of dendritic spines and axonal terminaux boutons is altered in J20s. (a,b) Quantification of spine (a; two-way RM ANOVA genotype F_(540,1) = 4.4, p = 0.04) and TB (b; two-way RM ANOVA genotype F_(461,1) = 13.7, p < 0.001) survival, as a fraction of the first time-point (30 weeks), in J20s and WT controls. (c,d) TOR, showing the change compared to the previous session, of spines (c; two-way RM ANOVA genotype F_(552,1) = 4.4, p = 0.04) and TBs (d; two-way RM ANOVA genotype F_(471,12) = 112.3, p < 0.001) in J20s and WT controls. (e) Average total turnover across all time points showed a significant difference in spine and TB TOR in the J20 group but not in the WTs (two-way ANOVA F_(103,1) = 6.3, p = 0.01). (f,g) Gains and losses of dendritic spines (f; two-way RM ANOVA gains genotype F_(552,1) = 5.6, p = 0.02; losses genotype F_(552,1) = 3.8, p = 0.06) and TBs (g; two-way RM ANOVA gains genotype F_(482,1) = 5.8, p = 0.02; losses genotype × age F_(482,12) = 2.5, p = 0.004) in J20s compared to WT controls. J20 spines n = 21, WT spines n = 34, J20 TBs n = 16, WT TBs n = 36. Error bars represent SEM.