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. 2019 Oct 16;9:14849. doi: 10.1038/s41598-019-51230-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Influence of CL variation on APD dispersion in LQT1. (A) Activation map and sample trace of action potentials. (B) Corresponding mean CLs (black) and ΔAPD_max-min (red) in panel (A,C) APD maps for each stimulation in A. The beat with maximum APD dispersion are marked with a red square (2^nd beat, ΔAPD_max-min = 16.3 ms, σ_APD = 3.91 ms). Prior to the maximum APD dispersion, CLs did not show a short-long CL pattern.