Table 1.
LMC | LQT1 | LQT2 | |
---|---|---|---|
Max σAPD |
Fig. 1. Under Random Stimulation: σAPD = 5.55 ms ΔAPDmax-min = 23.4 ms Under S1S1 Stimulation: CL = 210 ms σAPD = 3.75 ms ΔAPDmax-min = 15.2 ms |
Fig. 2. Under Random Stimulation: σAPD = 3.91 ms ΔAPDmax-min = 12.2 ms Under S1S1 Stimulation: CL = 240 ms σAPD = 2.62 ms ΔAPDmax-min = 12.2 ms |
Fig. 3. Under Random Stimulation: σAPD = 10.9 ms ΔAPDmax-min = 38.0 ms Under S1S1 Stimulation: CL = 270 ms σAPD = 7.2 ms ΔAPDmax-min = 26.0 ms |
Beat-to-beat APD variation (standard deviation of APD during random stimulation,σbeat-to-beat) |
5.8 ± 1.2 ms n = 5 hearts in Fig. 1 |
3.2 ± 0.9 ms n = 5 hearts in Fig. 2 |
8.8 ± 2.0 ms LMC vs. LQT2, p < 0.05 LQT1 vs. LQT2, p < 0.05 (Student’s t-test respectively) |
ΔCL = CLn−1 – CLn−2 at maximum APD dispersion (paired t-test between CLn−1 and CLn−2) (Fig. 4A) |
5.3 ± 17.7 ms p = 0.2084 n = 5 hearts, 10 scans |
5.0 ± 18.6 ms p = 0.2084 n = 5 hearts, 10 scans |
17.7 ± 14.1 ms CLn−1 > CLn−2, p < 0.01 n = 5 hearts, 10 scans |
Correlation of σAPD vs. ΔCL under random stimulation (Fig. 4B) |
0.008 ± 0.002 r = 0.23 ± 0.14 n = 4 hearts LMC vs. LQT1, p < 0.05 |
0.002 ± 0.004 r = 0.10 ± 0.16 n = 4 hearts |
0.022 ± 0.008 r = 0.51 ± 0.17 n = 4 hearts LMC vs. LQT2, p < 0.05 LQT1 vs. LQT2, p < 0.05 (Student’s t-test respectively) |
Correlation between ΔCL and σAPD under S1S2S3 stimulation (Fig. 4C) |
r = 0.68 ± 0.09 p < 0.05 n = 4 hearts |
N/A |
r = 0.79 ± 0.14 p < 0.01 n = 4 hearts |
Slope of σAPD vs. ΔCL under S1S2S3 stimulation (Fig. 4C) |
0.005 ± 0.001 n = 4 hearts |
N/A |
0.035 ± 0.020 LMC vs. LQT2, p < 0.01 n = 4 hearts (Student’s t-test) |
Coefficient α1 under random stimulation in Fig. 5C (Statistical differences were found by one-way ANOVA test at p = 0.05 level) |
0.23 ± 0.06 n = 6 hearts |
0.17 ± 0.02 n = 6 hearts LMC vs LQT1, p = 0.029 (Student’s t-test) |
0.32 ± 0.06 n = 6 hearts LMC vs LQT2, p = 0.039 LQT1 vs LQT2, p < 0.00003 (Student’s t-test respectively) |
Coefficient α2 under random stimulation in Fig. 5C (Statistical differences were found by one-way ANOVA test at p = 0.05 level) |
−0.068 ± 0.04505 n = 6 hearts |
0.007 ± 0.051 n = 6 hearts LMC vs LQT1, p = 0.023 (Student’s t-test) |
−0.053 ± 0.021 n = 6 hearts LQT1 vs LQT2, p = 0.025 LMC vs LQT2, p = 0.461 (Student’s t-test) |
Standard deviation of restitution slope map under random stimulation in Fig. 5D |
0.030 ± 0.014 n = 4 hearts |
0.029 ± 0.008 n = 4 hearts |
0. 064 ± 0.025 n = 4 hearts LMC vs. LQT2, p < 0.05 (Student’s t-test) |
Correlation between α1 and α2 in Fig. 5E |
−0.07 ± 0.15 n = 6 hearts |
N/A |
−0.27 ± 0.10 n = 6 hearts |