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. 2019 Oct 16;9:14845. doi: 10.1038/s41598-019-51328-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enriched biological process in PB and ICV from the cows with diffuse lesions versus the control group. The defense response (GO:0006952) and immune response (GO:0006955) biological processes were both enriched in the PB and ICV gene expression profiles from the cows with diffuse lesions. The heatmaps represent the fold change (log₂ fold) of the up- and downregulated genes included in the enriched GO:0006952 and GO:0006955. Colors and intensities depend on expression levels. Red indicated gene downregulation and blue upregulation.