Table 4.
The top 3 up- and downregulated genes in the PB and/or ICV samples of infected animals with focal and/or diffuse lesions versus control samples.
| Sample | Comparison | Gen ID | Description (Gene Symbol) | Lesion | Fold Change (Log2)a |
|---|---|---|---|---|---|
| PB | Focal vs. Control + Diffuse vs. Control | ENSBTAG00000019348 | Uncharacterized protein | Focal | 2.0 |
| Diffuse | 1.6 | ||||
| ENSBTAG00000004547 | Oxidized low density lipoprotein receptor1 (OLR1) | Focal | 1.1 | ||
| Diffuse | 2.3 | ||||
| ENSBTAG00000011007 | Tweety family member 2 (TTYH2) | Focal | 1.3 | ||
| Diffuse | 1.7 | ||||
| ENSBTAG00000001032 | Glycogen phosphorylase (PYGM) | Focal | −3.8 | ||
| Diffuse | −2.7 | ||||
| ENSBTAG00000019406 | Insulin growth factor2 mRNA binding prot3 (IGF2BP3) | Focal | −4.0 | ||
| Diffuse | −2.8 | ||||
| ENSBTAG00000010738 | C-C motif chemokine ligand 14 (CCL14) | Focal | −4.5 | ||
| Diffuse | −5.3 | ||||
| ICV | Focal vs. Control + Diffuse vs. Control | ENSBTAG00000022937 | Intelectin 2 precursor (ITLN2) | Focal | 10.6 |
| Diffuse | 6.8 | ||||
| ENSBTAG00000010632 | Fatty acid binding protein 6 (FABP6) | Focal | 4.2 | ||
| Diffuse | 4.7 | ||||
| ENSBTAG00000039035 | Heat shock protein family A member 6 (HSPA6) | Focal | 4.2 | ||
| Diffuse | 5.8 | ||||
| ENSBTAG00000047181 | Multidrug resistance-associated protein 4 | Focal | −3.2 | ||
| Diffuse | −2.3 | ||||
| ENSBTAG00000020184 | Aquaporin 8 (AQP8) | Focal | −3.2 | ||
| Diffuse | −4.5 | ||||
| ENSBTAG00000013055 | Duodenase-1-like | Focal | −3.6 | ||
| Diffuse | −2.0 | ||||
| PB + ICV | Focal vs. Control | ENSBTAG00000036154 | TCR gamma alternate reading frame protein (TARP) | Blood | −2.8 |
| ICV | −1.1 | ||||
| ENSBTAG00000002362 | Apolipoprotein L domain containing 1 (APOLD1) | Blood | −2.6 | ||
| ICV | −1.1 | ||||
| ENSBTAG00000038080 | Duodenase-1 | Blood | −2.2 | ||
| ICV | −1.9 | ||||
| Diffuse vs. Control | ENSBTAG00000011467 | Basic ATF transcription factor2 (BATF2) | Blood | 2.6 | |
| ICV | 2.8 | ||||
| ENSBTAG00000001725 | C-X-C motif chemokine ligand 10 (CXCL10) | Blood | 2.0 | ||
| ICV | 2.2 | ||||
| ENSBTAG00000046803 | Growth arrest specific 1 (GAS1) | Blood | 2.4 | ||
| ICV | 1.1 | ||||
| ENSBTAG00000039196 | C4b-binding protein alpha-like | Blood | −4.8 | ||
| ICV | −2.0 | ||||
| ENSBTAG00000010273 | Epiregulin (EREG) | Blood | −4.8 | ||
| ICV | −2.0 | ||||
| ENSBTAG00000019716 | C-X-C motif chemokine ligand 8 (CXCL8) | Blood | −3.9 | ||
| ICV | −1.9 |
aA negative fold-change value reports downregulated gene expression.