Figure 3.

Percent change in mixed effects model means over 96 weeks.

Change in the mixed effects model means over 96 weeks shown with error bars representing the 95% confidence intervals. While the NAA/tCr ratio changes in opposite directions for the ocrelizumab and interferon beta-1a treated cohorts, these groups show the same direction of change in NAA over time. The opposing change in the NAA/tCr ratio arises from different directions of change in the tCr concentrations over time, thus the absolute concentrations are necessary for accurate interpretation of metabolic changes. The only difference between groups with p < 0.05 is the difference in the change in mI concentration over time between the two treatment arms.