Table 2.
DNA Methylation and Hydroxymethylation at Kcnq1.
| Sample | Exposure | Na | % DNA methylation (SD) |
P value (Mann-Whitney test) |
Beta valuec (P Value) |
|---|---|---|---|---|---|
| 5mC RCb | Control | 5 | 87.0 (7.0) | 0.6 | 1.2 (0.7) |
| BPA | 5 | 86.2 (5.6) | |||
| 5hmC RC | Control | 5 | 5.4 (7.3) | 0.6 | |
| BPA | 5 | 6.6 (5.9) | |||
| 5mC Midb | Control | 5 | 84.8 (10.6) | 0.8 | -4.0 (0.4) |
| BPA | 5 | 89.0 (2.0) | |||
| 5hmC Mid | Control | 5 | 8.6 (10.9) | 0.9 | |
| BPA | 5 | 4.6 (1.5) |
aNumber of samples that passed pyrosequencing quality control and were included in statistical analysis. bRC, Right Cortex, Mid, Midbrain. cBeta value is the interaction term calculated using a linear mixed effects model. Methylation category (5mC or 5hmC), exposure group, and sex were included as terms in all models.