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. 2012 Jan 25;32(4):1311–1328. doi: 10.1523/JNEUROSCI.2755-11.2012

Figure 11.

Figure 11.

Impaired postnatal downregulation of PLCβ3 immunoreactivity in aldolase C/zebrin II-negative compartments of PC-Cav2.1 KO mice. A–H, Immunofluorescence for PLCβ3 (A1–H1) and PLCβ4 (A2–H2) in control (A–C), PC-Cav2.1 KO (D–F), GC-Cav2.1 KO (G), and global Cav2.1 KO (H) mice at P7 (A, D), P14 (B, E), and P21 (C, F, G, H). I, J, Histograms showing the relative intensity gap of PLCβ3 (I) or PLCβ4 (J) immunoreactivity between intensely labeled and weakly labeled compartments. The values for PLCβ3 are as follows: 185.4 ± 9.9% in control and 128.3 ± 4.6% in PC-Cav2.1 KO mice at P14, p < 0.001; 181.7 ± 6.6% in control and 139.1 ± 3.6% in PC-Cav2.1 KO mice at P21, p < 0.0001. The values for PLCβ4 are as follows: 269.1 ± 22.3% in control and 257.0 ± 15.0% in PC-Cav2.1 KO mice at P14, p = 0.76; 346.3 ± 29.9% in control and 299.7 ± 30.2% in PC-Cav2.1 KO mice at P21, p = 0.17 (mean ± SEM, n = 3 mice, U test). Numerals 3–6 indicate the lobule number. ***p < 0.001. Scale bars, 100 μm.