Table 1.
Comparison of dinucleotide content within primary vs. secondary DMRs (P values)
| CpG | GpC | ApT | TpA | ApA+ TpT |
ApC+ GpT |
ApG+ CpT |
CpA+ TpG |
CpC+ GpG |
GpA+ TpC |
|
|---|---|---|---|---|---|---|---|---|---|---|
| Pat1° vs. Mat1° | 0.0240 | 0.0139 | 0.0004 | 0.0444 | 0.4542 | 0.2515 | 0.9681 | 0.0074 | 0.0461 | 0.7065 |
| Pat2° vs. Mat2° | 0.4963 | 0.9369 | 0.9178 | 0.9987 | 0.3756 | 0.1281 | 0.2590 | 0.9287 | 0.7013 | 0.6743 |
| Pat1° vs. Pat2° | 0.0861 | 0.0835 | 0.0102 | 0.0387 | 0.2490 | 0.3482 | 0.6532 | 0.0768 | 0.0486 | 0.5086 |
| Mat1° vs. Mat2° | 0.7422 | 0.6371 | 0.7383 | 0.4821 | 0.6925 | 0.1175 | 0.2031 | 0.8800 | 0.9646 | 0.9638 |
| Pat1° vs. Mat2° | 0.1057 | 0.0472 | 0.0160 | 0.0218 | 0.7908 | 0.0570 | 0.2808 | 0.0187 | 0.1886 | 0.7569 |
| Pat2° vs. Mat1° | 0.5735 | 0.7343 | 0.8067 | 0.5679 | 0.4508 | 0.6926 | 0.6236 | 0.9804 | 0.6192 | 0.6434 |
(Pat1° paternally methylated primary DMR, Mat1° maternally methylated primary DMR, Pat2° paternally methylated secondary DMR, Mat2° maternally methylated secondary DMR. Frequency of each dinucleotide was determined as described in “Methods”. P values were calculated using a two-tailed t test for independent samples as described in “Methods”. Raw data are found in Additional file 3