Table 2.
Histological alterations in the livers of dogs with and without positive splenic aspirate culture
| Histological alteration | With positive splenic aspirate culture (N = 68) | Without positive splenic aspirate culture (N = 80) |
|---|---|---|
| n (%) | n (%) | |
| Portal inflammation | 67 (99)** | 72 (90) |
| Intrasinusoidal granulomas | 44 (65) | 43 (54) |
| Kupffer cell hyperplasia | 43 (63) | 55 (69) |
| Kupffer cell hypertrophy | 39 (57) | 51 (64) |
| Portal granulomas | 24 (35)*** | 6 (8) |
| Intrasinusoidal lymphocytosis | 51 (75) | 64 (80) |
| Congestion of sinusoids | 8 (12) | 13 (16) |
| Dilation of sinusoids | 10 (15) | 17 (21) |
| Intrasinusoidal aggregates | 38 (56) | 47 (59) |
| Perivascular inflammation | 66 (97) | 74 (93) |
| Hepatocyte steatosis | 14 (21) | 14 (18) |
| Ballooning of hepatocytes | 20 (29)* | 11 (14) |
| Hepatocyte necrosis | 10 (15) | 15 (19) |
* P < 0.05, ** P < 0.01, *** P < 0.005