Fig. 4.
Regulon activities of the lncRNA-based consensus clusters. a Mean regulon activities in lncRNA clusters for 16 regulators in the TCGA and NAC cohorts. Asterisks mark clusters that were significantly enriched (Fisher’s exact test, Benjamin Hochberg adjusted, p < 10−3) with activated or repressed samples for a regulon. Regulons activities in the TCGA cohort for b SHH and c FGFR3, with TP53, FGFR3, and RB1 mutation status and LPL-C3 vs. LPL-Other indicated in covariate tracks. A dark black bar indicates a mutation event