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. 2019 Oct 16;17:343. doi: 10.1186/s12967-019-2091-0

Fig. 5.

Fig. 5

Proposed model of PYCR1 interference on HCC cell proliferation and apoptosis. PYCR1 interference could inhibit IRS1 expression and insulin resistance via JNK signaling pathway suppression, which subsequently inhibited HCC cell proliferation and promoted cell apoptosis