Table 4.
Biomarker values in infants with and without disability.
| Normal outcome/minor disability | Moderate/severe disability | Moderate/severe disability and deaths | Difference (95% CI)⁎ | P value | |
|---|---|---|---|---|---|
| Lac/NAA | N = 45 | N = 12 | N = 26 | ||
| Arithmetic mean (SD) | 0.136 (0.067) | 0.816 (1.13) | 1.287 (1.500) | 1.151 (1.59 to 0.707) | P < .0011 |
| Coefficient of variationa | 0.654 | 1.351 | 1.462 | ||
| Median [IQR] | 0.142 [0.080 to 0.185] | 0.600 [0.237 to 0.774] | 0.770 [0.392 to 1.575] | 0.628 (−0.370 to 4.684) | P = .0052 |
| Fractional Anisotropy | N = 44 | N = 12 | N = 22 | ||
| Arithmetic mean (SD) | 0.422 (0.034) | 0.354 (0.051) | 0.368 (0.055) | −0.055 (−0.033 to −0.077) | P < .0013 |
| Coefficient of variationb | 0.080 | 0.144 | 0.149 | ||
| Median [IQR] | 0.420 [0.403 to 0.445] | 0.358 [0.310 to 0.402] | 0.382 [0.328 to 0.401] | −0.038 (−0.09 to −0.053) | P < .0012 |
⁎
Difference between the moderate/severe disability and deaths group and the normal outcome/minor disability group.
a
This is sqrt(exp(var)-1) where var. is the variance on the log scale.
b
This is the ratio of the standard deviation to the arithmetic mean in the original untransformed data.
1
Two group t-test of means of Lac/NAA on the log scale, in normal outcome/mild disability and moderate/severe disability/deaths groups.
2
Wilcoxon rank-sum test, in normal outcome/mild disability and moderate/severe disability/deaths groups.
3
Two group t-test of means of FA, in normal outcome/mild disability and moderate/severe disability/deaths groups.